八爪悅讀，創造幸福！1月19日366卷第3期的新鮮NEJM，很值得看的醫學前沿進展！
【原始論文】
1.?皮膚鱗狀細胞癌患者中接受BRAF抑制劑治療的RAS基因突變
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
[評論] ?環繞邊緣——BRAF抑制劑的悖論
RAF around the Edges — The Paradox of BRAF Inhibitors
2.?丙肝基因型1的抗病毒藥物的兩個初步研究
Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
[評論] ?丙型肝炎治療的分水嶺時刻
A Watershed Moment in the Treatment of Hepatitis C
3.?老年女性骨質疏松的骨密度測試間隔與轉型
Bone-Density Testing Interval and Transition to Osteoporosis in Older Women
4. **非上皮卵巢癌的反復DICER1體基因突變**
Recurrent Somatic?DICER1?Mutations in Nonepithelial Ovarian Cancers
5.?簡報：甲狀腺激素受體的α基因突變
Brief Report: A Mutation in the Thyroid Hormone Receptor Alpha Gene
【MGH病例報道】
63歲女性出現呼吸困難及進行性的呼吸衰竭
Case 2-2012 — A 63-Year-Old Woman with Dyspnea and Rapidly Progressive Respiratory Failure
【綜述】
當前概念：冠脈搭橋術后的認知與神經系統預后
Current Concepts: Cognitive and Neurologic Outcomes after Coronary-Artery Bypass Surgery
【觀察】
1. 減輕痛苦101——止痛在美國
Alleviating Suffering 101 — Pain Relief in the United States
2. 痛苦的不公平現象——發展中國家姑息治療
Painful Inequities — Palliative Care in Developing Countries
3.?阿托伐他汀和醫療保健費用
Generic Atorvastatin and Health Care Cost(免費全文)
【臨床圖片】
1. 椎體術后的肺栓塞?Pulmonary Cement Embolism after Vertebroplasty?(免費全文)
2.Tophaceous痛風?Tophaceous Gout(免費全文)